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| | Name | aak-2 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | Recessive |
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| Strain | N2 |
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| Description | The aak-2(ok524) allele shortens life-span by approximately 12% (Apfeld et al., 2004). |
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| Gene Function | AMP-activated protein kinase |
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| Other Phenotypes | A lipofuscin-like fluorescent pigment that accumulates in an age-dependent manner in the intestine accumulates faster in aak-2 mutants, consistent with the idea that aak-2 mutation accelerates aging (Apfeld et al., 2004). |
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| Homologs | S.c. SNF1
C.e. aak-2
D.m. SNF1A
H.s. AMPKalpha1
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| Primary Reference | Apfeld, J., O'Connor, G., McDonagh, T., Distefano, P. S., and Curtis, R. (2004). The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. [Abstract]
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| Other References | |
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| Relevant Links | |
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| Keywords | ATP, energy, calorie restriction, caloric restriction, worm |
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