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| | Name | C/EBP |
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| Organism | Mus musculus |
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| Aging Phenotype | Life-span extension |
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| Allele Type | N/A |
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| Strain | C57BL/6J |
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| Description | Replacement of the C/EBP alpha gene with the C/EBP beta gene results in a 20% increase in mean life-span (Chiu et al., 2004). |
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| Gene Function | CCAAT enhancer binding protein involved in fat cell differentiation and maturation |
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| Other Phenotypes | Beta/beta animals consume more food but weigh less than control animals (Chen et al., 2000), and have a slightly elevated body temperature (0.3-0.5 degrees C) (Chiu et al., 2004).
Beta/beta animals show an increase in mitochondrial biogenesis only in fat cells from white adipose tissue (Chiu et al., 2004). |
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| Homologs | |
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| Primary Reference | Chiu, C. H., Lin, W. D., Huang, S. Y., and Lee, Y. H. (2004). Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev. [Abstract]
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| Other References | Chen, S. S., Chen, J. F., Johnson, P. F., Muppala, V., and Lee, Y. H. (2000). C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol 20, 7292-7299. [Abstract]
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| Relevant Links | LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=12606
LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=12608
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| Keywords | adipocyte, mitochondria, calorie, caloric restriction, fat |
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