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| | Name | BubR1 |
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| Organism | Mus musculus |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | Deletion |
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| Strain | C57/BL6 |
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| Description | Median life-span was 6 months in hypomorphic Bub1b H/H mice compared to 15 months in wild-type animals (Baker et al., 2004). Bub1b H/H mice develop many phenotypes suggesive of accelerated aging, including: progressive bilateral cataracts, substantial loss of sub dermal adipose tissue, spinal kyphosis, muscle atrophy, and decreased wound healing. In addition, there is a pronounced increase in senescent associated β-gal expression in late generation Bub1b H/H mice, indicative of increased rate of cellular senescence. |
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| Gene Function | Spindle assembly checkpoint protein. |
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| Other Phenotypes | Homozygous knock-out of Bub1b results in lethality (Baker et al., 2004). Heterozygous animals show no accelerated aging phenotypes. |
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| Homologs | S.c. Mad3, Bub1
S.p. Mad3
C.e. Bub-1
D.m. BUB1
R.n. BUB1B
M.m. BUB1
H.s. BUB1B, BUB1
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| Primary Reference | Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., and van Deursen, J. M. (2004). BubR1 insufficiency causes early onset of aging-associated phenotypes and inferti [Abstract]
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| Other References | |
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| Relevant Links | LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=12236
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| Keywords | spindle assembly defect, cellular senescence, aneuploidy, infertility, mouse, premature aging, progeria |
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