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| | Name | CETP |
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| Organism | Homo sapiens |
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| Aging Phenotype | Correlation |
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| Allele Type | Recessive |
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| Strain | Ashkenazi Jewish |
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| Description | Homozygosity for the I405V variant of CETP is associated with exceptional longevity among Ashkenazi Jews (Barzilai et al., 2003). |
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| Gene Function | Cholesteryl ester transfer protein is involved in the regulation of cholesterol transport and high-density lipoprotein (HDL) levels. |
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| Other Phenotypes | Homozygosity for the I405V allele is associated with larger HDL and LDL particle sizes as well as a lower prevalence of hypertension, cardiovascular disease, and metabolic disease (Barilai et al., 2003). |
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| Homologs | |
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| Primary Reference | Barzilai, N., G. Atzmon, C. Schechter, E. J. Schaefer, A. L. Cupples et al., 2003 Unique lipoprotein phenotype and genotype associated with exceptional longevity. Jama 290: 2030-2040. [Abstract]
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| Other References | |
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| Relevant Links | OMIM: http://www.ncbi.nlm.nih.gov:80/entrez/dispomim.cgi?id=118470
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=1071
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| Keywords | Homo sapiens, human, heart disease, cholesterol, fat, diabetes, insulin resistance, centenarian |
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