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| | Name | bec-1 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | RNAi |
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| Strain | N2 |
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| Description | RNAi of bec-1 shortens median life-span by approximately 14% and prevents life-span extension by daf-2(e1370) (Melendez et al., 2003). |
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| Gene Function | Protein involved in autophagy. |
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| Other Phenotypes | RNAi of bec-1 caused the formation of abnormal dauers in a daf-2(e1370) background (Melendez et al., 2003). |
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| Homologs | S.c. VPS30
S.p. Spac20g8.10cp
D.m. CG5429
R.n. BECN1
M.m. BECN1
BECN1
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| Primary Reference | Melendez, A., Z. Talloczy, M. Seaman, E. L. Eskelinen, D. H. Hall et al., 2003 Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans. Science 301: 1387-1391. [Abstract]
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| Other References | |
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| Relevant Links | WormBase: http://www.wormbase.org/db/misc/etree?name=bec-1&class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=177345
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| Keywords | autophagy, worm, insulin signaling |
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