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| | Name | CTF4 |
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| Organism | Saccharomyces cerevisiae (replicative) |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | Recessive |
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| Strain | 7585-2-2 |
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| Description | Deletion of CTF4 results in an approximately 75% reduction in mean life-span (Hoopes et al., 2002). |
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| Gene Function | DNA polymerase alpha binding protein involved in regulating replication initiation |
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| Other Phenotypes | |
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| Homologs | |
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| Primary Reference | Hoopes, L. L., Budd, M., Choe, W., Weitao, T., and Campbell, J. L. (2002). Mutations in DNA replication genes reduce yeast life span. Mol Cell Biol 22, 4136-46. [Abstract]
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| Other References | |
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| Relevant Links | SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ctf4
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| Keywords | DNA damage, rDNA, recombination, replication, stalled replication fork, replication fork block, nucleolus cell cycle, DNA, yeast, replicative senescence, Saccharomyces, cerevisiae |
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