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| | Name | CDC7 |
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| Organism | Saccharomyces cerevisiae (replicative) |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | Recessive |
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| Strain | Unknown |
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| Description | Transient inactivation of CDC7 resulted in a shortened life-span (Jazwinski et al., 1989) |
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| Gene Function | Required for intitiation of DNA replication. |
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| Other Phenotypes | The CDC7 gene plays a role in silencing (Axelrod and Rine, 1991), and RAS2 modulates the activity of CDC7. |
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| Homologs | S.p. HSK1, SPO4
H.s. CDC7
M.m. CDC7
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| Primary Reference | Jazwinski, S. M., Egilmez, N. K., and Chen, J. B. (1989). Replication control and cellular life span. Exp Gerontol 24, 423-36. [Abstract]
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| Other References | Axelrod, A., and Rine, J. (1991). A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol Cell Biol 11, 1080-91. [Abstract]
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| Relevant Links | SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=cdc7
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| Keywords | silencing, yeast, replicative life-span |
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