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| | Name | daf-19 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | Bristol N2 |
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| Description | Loss of function increases life span up to 50% (Apfeld and Kenyon 1999). |
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| Gene Function | RFX-type transcription factor (Swoboda et al. 2000). |
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| Other Phenotypes | Mutants are dauer constitutive, dye-filling defective, and lack sensory cilia (Riddle et al., 1981; Collet et al., 1998). |
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| Homologs | S.c. RFX1
S.p. sak1
D.m. RFX
M.m. RFX2, RFX1, RFX3
H.s. RFX2, RFX3, RFX1
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| Primary Reference | Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
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| Other References | Collet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E., and Herman, R. K. (1998). Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. Genetics 148, 187-200. [Abstract]
Riddle, D. L., Swanson, M. M., and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-71. [Abstract]
Swoboda, P., Adler, H. T., and Thomas, J. H. (2000). The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Mol Cell 5, 411-21. [Abstract]
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| Relevant Links | WormBase: http://www.wormbase.org/db/gene/locus?name=daf-19;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=174577
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| Keywords | Caenorhabditis, elegans, worm, transcription factor, dauer, neurons |
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