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| | Name | beach1 |
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| Organism | Drosophila melanogaster |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | Deletion |
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| Strain | unknown |
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| Description | Mutation of beach1 results in a 40-45% decrease in mean life-span (Finley et al., 2003). |
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| Gene Function | Intracellular protein transport, lysosomal transport. |
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| Other Phenotypes | Beach1 mutants display an age-related neurodegenerative phenotype with reduced CNS size and altered morphology (Finley et al., 2003). Mutation of beach1 also results in an accumulation of insoluble ubiquinated proteins and amyloid precursor-like proteins along with an increase in neuronal apoptosis (Finley et al., 2003). |
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| Homologs | S.c. BPH1
M.m. CHS1, FAN,
H.s. LRBA, CHS1, FAN
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| Primary Reference | Finley, K. D., Edeen, P. T., Cumming, R. C., Mardahl-Dumesnil, M. D., Taylor, B. J., Rodriguez, M. H., Hwang, C. E., Benedetti, M., and McKeown, M. (2003). blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J [Abstract]
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| Other References | |
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| Relevant Links | FlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0043362
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=33819
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| Keywords | APPL, aggregates, ubiquinated, bchs, thioflavine S., neurodegenerative |
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