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| | Name | daf-18 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | No effect on life-span |
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| Allele Type | Recessive |
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| Strain | Bristol N2 |
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| Description | daf-18 mutants can partially suppress the life span extension of age-1 and daf-2 mutants (Larsen et al., 1995). |
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| Gene Function | PTEN phosphatase. |
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| Other Phenotypes | daf-18 mutants are defective for dauer formation; forms some dauer-like larvae when starved (Dorman et al. 1995; Larsen et al. 1995) |
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| Homologs | S.c. TEP1, CDC14
S.p. Spbc609.02p
C.e. F46F11.3, T12B3.D
D.m. PTEN, CG5671, CG1107
R.n. Rn.2218, Rn.11012
M.m. PTEN
H.s. PTEN, TPTE, GAK, FLJ10923
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| Primary Reference | Larsen, P. L., Albert, P. S., and Riddle, D. L. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-83. [Abstract]
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| Other References | Dorman, J. B., Albinder, B., Shroyer, T., and Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-406. [Abstract]
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| Relevant Links | WormBase: http://www.wormbase.org/db/gene/locus?name=daf-18;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176869
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| Keywords | metabolism, insulin, signaling, dauer, Caenorhabditis, elegans, worm, dauer |
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