gene db

Name	daf-12
Organism	Caenorhabditis elegans
Aging Phenotype	Life-span extension
Allele Type	Recessive
Strain	Bristol N2
Description	Recessive loss of function mutation shortens life span but activity is required for extension of life span after germ line ablation (Hsin and Kenyon, 1999) and can extend a daf-2 mutant life span (Larsen et al., 1995).
Gene Function	Predicted steroid hormone receptor, no known ligand. Required for dauer formation (Riddle et al., 1981)
Other Phenotypes	Mutant is dauer defective, heterochronic (Riddle et al., 1981). Mutation of daf-12 suppresses life span extension by a mutation in daf-28 (Malone et al., 1996). Some alleles of daf-12 show synthetic lethality with mutation of age-1 (Malone et al., 1996) or mutation of daf-2 (Vowels and Thomas, 1992).
Homologs	C.e. NHR-48, NHR-8, RO9G11.2, nhr-3, sex-1, nhr-23 ... D.m. Hr96, EcR, Hnf4, CG9310, CG7404, Hr46 ... R.n. Vdr, Rn.42943, Esr2, Rn.23656, Thra1, Rn.42941 ... M.m. Nr1i2, Vdr, Nr1i3, Nr1h4, Rarg, Esrra ... H.s. NR1I2, VDR, LXRA, CAR, RIP14, RARB ...
Primary Reference	Hsin, H., and Kenyon, C. (1999). Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-6. [Abstract] Larsen, P. L., Albert, P. S., and Riddle, D. L. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-83. [Abstract]
Other References	Malone, E. A., Inoue, T., and Thomas, J. H. (1996). Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143, 1193-205. [Abstract] Riddle, D. L., Swanson, M. M., and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-71. [Abstract] Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Relevant Links	WormPD: http://www.proteome.com/databases/WormPD/reports/daf-12.html WormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=daf-12 LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=181263
Keywords	Caenorhabditis, elegans, worm, insulin, signaling, transcription factor, dauer