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| | Name | B0261.4 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Life-span extension |
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| Allele Type | RNAi |
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| Strain | N2 |
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| Description | RNAi of the B0261.4 gene extends life-span by 18% (Lee et al., 2003). Life-span extension by RNAi of B0261.4 is not suppressed by daf-16. |
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| Gene Function | Mitochondrial ribosomal subunit. |
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| Other Phenotypes | B0261.4 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003). |
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| Homologs | H.s. MRPL47
S.c. MRP14
S.p. Spcc4g3.06c
D.m. RLC1
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| Primary Reference | Lee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
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| Other References | |
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| Relevant Links | WormBase: http://www.wormbase.org/db/gene/gene?name=B0261.4
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172164
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| Keywords | mitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm |
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