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| | Name | daf-10 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | Bristol N2 |
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| Description | Loss of function mutation increases life span up to 60% (Apfeld and Kenyon 1999). |
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| Gene Function | Not cloned. |
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| Other Phenotypes | Mutants are dauer defective, dye filling defective, octopamine deficient and have abnormal chemotaxis and osmotic avoidance. Mutants also display abnormal sensory anatomy, especially amphidial neurons and sheath cells, and cephalic neurons. Males do not mate (Perkins et al., 1986). |
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| Homologs | N/A
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| Primary Reference | Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
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| Other References | Perkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract]
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| Relevant Links | WormBase: http://www.wormbase.org/db/gene/locus?name=daf-10;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=184883
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| Keywords | Caenorhabditis, elegans, worm, neurons, dauer |
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