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| | Name | ced-3 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | No effect on life-span |
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| Allele Type | Recessive |
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| Strain | N2 |
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| Description | The ced-3(n1286) allele has no effect on life-span (Garigan et al., 2002). |
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| Gene Function | Caspase. |
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| Other Phenotypes | ced-3(n1286) animals are defective for apoptosis. |
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| Homologs | D.m. ICE, DCP-1
R.n. CASP2, CASP1
M.m. CASP7, CASP3, CASP2, CASP6, CASP8 ...
H.s. CASP3, CASP7, CASP6, CASP2, CASP8 ...
D.m. ICE, DCP-1
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| Primary Reference | Garigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-12. [Abstract]
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| Other References | |
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| Relevant Links | WormBase: http://www.wormbase.org/db/seq/sequence?name=ced-3;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=178272
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| Keywords | worm, programmed cell death, apoptosis, signaling |
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