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| | Name | daf-1 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | No effect on life-span |
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| Allele Type | Recessive |
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| Strain | N2 |
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| Description | The daf-1(m40) allele has no effect on life-span and fails to prevent life-span extension by sir-2.1 (Tissenbaum and Guarente, 2001). |
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| Gene Function | Type I TGF-beta receptor. |
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| Other Phenotypes | Mutation of daf-1 results in a temperature-sensitive, dauer-constitutive phenotype in larvae. Overexpression of a href="http://sageke.sciencemag.org/cgi/genedata/sagekeGdbGene;136">sir-2.1 in the daf-1(m40) background results in an increase in the severity of the dauer-constitutive phenotype (Tissenbaum and Guarente, 2001). |
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| Homologs | S.c. CTK1
S.p. NAK1
C.e. daf-4, sma-6
R.n. ACVR2B, ACVR2, TGFBR2, TGFBR1
M.m. ACVR2, ACVR2B, TGFBR2, TGFBR1
H.s. ACVR2B, ACVR2, TGFBR2, TGFBR1
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| Primary Reference | Tissenbaum, H. A., and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-30. [Abstract]
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| Other References | |
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| Relevant Links | WormBase: http://www.wormbase.org/db/gene/locus?name=daf-1;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176829
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| Keywords | metabolism, insulin, signaling, dauer, Caenorhabditis, elegans, worm, stress, |
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