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| | Name | cher |
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| Organism | Drosophila melanogaster |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Overexpression |
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| Strain | PdL x rtTA; Oregon-R x rtTA |
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| Description | Overexpression of filamin from a doxycycline-inducible promoter results in a 7-9% increase in mean life-span (Landis et al., 2003). |
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| Gene Function | Actin-binding protein. |
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| Other Phenotypes | Filamin is involved in cytokinesis and ring canal formation (Li et al., 1999; Sokol and Cooley, 1999).
Drosophila filamin binds to both Drosophila and human presenilins,and filamin interacts genetically with presenilin in Drosophila (Guo et al., 2000). |
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| Homologs | S.c. FIMB
R.n. PLE1, SPCP
M.m. AAC2, AAC3, SPCO
H.s. FLNA, AAC2, AAC3, SPCO
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| Primary Reference | Landis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd, and CctI genes. Genome Biology 4, R8.
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| Other References | Li, M. G., Serr, M., Edwards, K., Ludmann, S., Yamamoto, D., Tilney, L. G., Field, C. M., and Hays, T. S. (1999). Filamin is required for ring canal assembly and actin organization during Drosophila oogenesis. J Cell Biol 146, 1061-74. [Abstract]
Sokol, N. S., and Cooley, L. (1999). Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canals. Curr Biol 9, 1221-30. [Abstract]
Guo, Y., Zhang, S. X., Sokol, N., Cooley, L., and Boulianne, G. L. (2000). Physical and genetic interaction of filamin with presenilin in Drosophila. J Cell Sci 113 Pt 19, 3499-508. [Abstract]
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| Relevant Links | FlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0014141
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=42066
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| Keywords | fly, cell structure, |
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