|
| | Name | Cct1 |
|---|
| Organism | Drosophila melanogaster |
|---|
| Aging Phenotype | Life-span extension |
|---|
| Allele Type | Overexpression |
|---|
| Strain | PdL x rtTA; Oregon-R x rtTA |
|---|
| Description | Overexpression of rdh from a doxycycline-inducible promoter results in a 6-8% increase in mean life-span (Landis et al., 2003). |
|---|
| Gene Function | CTP:phosphocholine cytidylyltransferase |
|---|
| Other Phenotypes | Cct1 catalyzes the conversion of phosphocholine to CDP-choline and is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway (Cornell and Northwood, 2000). |
|---|
| Homologs | S.c. PCT1, ECT1
S.p. ECT1
C.e. F08C6.2
R.n. PCYT1A, PCYT1B
M.m. PCYT1A, PCYT1B
H.s. PCYT1A, PCYT1B
|
|---|
| Primary Reference | Landis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd, and CctI genes. Genome Biology 4, R8.
|
|---|
| Other References | Cornell, R. B., and Northwood, I. C. (2000). Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem Sci 25, 441-7. [Abstract]
|
|---|
| Relevant Links | FlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0041342&resultlist=fbgn19107.data[0]
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=117353
|
|---|
| Keywords | fly, signaling |
|---|
|