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| | Name | CYR1 |
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| Organism | Saccharomyces cerevisiae (replicative) |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | A364A, PSY316 |
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| Description | The cdc35-1 allele confers a 75% extension of replicative life-span at 25°C (Lin et al., 2000). CYR1 appears to be in the same genetic pathway for longevity as SIR2 and NPT1 and has been suggested as a genetic model for caloric restriction (Lin et al., 2000). |
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| Gene Function | Adenylate cyclase. Generates cAMP in response to RAS activation. |
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| Other Phenotypes | Null mutant arrest at G1 phase is rescued by exogenous cAMP (Matsumoto et al., 1982). A transposon mutagenized allele of CYR1 results in a 90% increase in chronological life-span (stationary phase survival) ,resistance to hydrogen peroxide, and resistance to heat shock (Fabrizio et al., 2001). |
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| Homologs | S.c. PTC1, SDS22, NUD1
S.p. ptc3, ptc1
C.e. F43C1.1, LET-413, SOC-2
D.m. CG5462, CG5407, SCRIB
M.m. SUR8, LRRN1, IMG
H. s. LOC55914
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| Primary Reference | Lin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
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| Other References | Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., and Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-90. [Abstract]
Matsumoto, K., Uno, I., Oshima, Y., and Ishikawa, T. (1982). Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 79, 2355-9. [Abstract]
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| Relevant Links | SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=cyr1
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| Keywords | caloric restriction, metabolism, signaling, cell cycle, replicative senescence, S. cerevisiae, yeast, stationary phase, oxidative stress |
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