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| | Name | cco-1 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Life-span extension |
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| Allele Type | RNAi |
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| Strain | N2 |
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| Description | RNAi of cco-1 by bacterial feeding increases life-span by 60% (Dillin et al., 2002). RNAi of cco-1 during larval stages is necessary and sufficient for increased life-span. RNAi of cco-1 only during adulthood fails to extend life-span. |
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| Gene Function | Cytochrome c oxidase. Component of the mitochondrial respiratory chain complex IV. |
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| Other Phenotypes | RNAi of cco-1 results in reduced pharyngeal pumping, defecation, and motility. ATP levels are reduced by 60- 80% in cco-1 animals and body size is reduced (Dillan et al., 2002).
Mutation of daf-16 fails to prevent life-span extension by RNAi of cco-1 and mutation of daf-2 further extends the life span of cco-1 RNAi animals. |
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| Homologs | H.s. COX5B
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| Primary Reference | Dillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-401. [Abstract]
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| Other References | |
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| Relevant Links | WormBase: http://www.wormbase.org/db/misc/etree?name=cco-1&class=Locus
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| Keywords | mitochondria, oxidative stress, metabolism, worm, ATP, respiration, electron transport chain, oxidative stress, ROS |
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