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| | Name | CAT (2) |
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| Organism | Drosophila melanogaster |
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| Aging Phenotype | No effect on life-span |
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| Allele Type | Overexpression |
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| Strain | Unknown |
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| Description | Targeted overexpression of CAT in the mitochondrial matrix has no effect on life-span at 25C and slightly shortens life-span at 29C (Mockett et al., 2003). |
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| Gene Function | Catalase is an antioxidant enzyme that converts hydrogen peroxide to water. |
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| Other Phenotypes | Targeted overexpression of CAT in the mitochondrial matrix results in increased resistance to endogenous hydrogen peroxide, paraquat, and cold stress (Mockett et al., 2003). No effect on metabolic rate, activity, or resistance to hypoxia was noted. It has been previously reported that simultaneous overexpression of catalase and superoxide dismutase extends life-span in flies (Orr and Sohal, 1994). |
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| Homologs | S.c. CTA1, CTT1
S.p. cta1
C.e. Y54G11A.6, CTL-2, CTL-1
D.m. CG9314
R.n. CAT
M.m. CAT
H.s. CAT
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| Primary Reference | Mockett, R. J., Bayne, A. V., Kwong, L. K., Orr, W. C., and Sohal, R. S. (2003). Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. Free Radic Biol Med 34, 207-17.
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| Other References | Orr, W. C., and Sohal, R. S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-30. [Abstract]
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| Relevant Links | FlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0000261
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=40048
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| Keywords | oxidative stress, fly, Drosophila, melanogaster, mitochondria |
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