|
| | Name | clk-1 |
|---|
| Organism | Caenorhabditis elegans |
|---|
| Aging Phenotype | Shortened life-span |
|---|
| Allele Type | Overexpression |
|---|
| Strain | Bristol N2 |
|---|
| Description | Overexpression of clk-1 increases mitochondrial activity and shortens life-span (Felkai et al., 1999). |
|---|
| Gene Function | Required for ubiquinone biosynthesis. Has strong similarity to the human ubiquinone biosynthesis protein COQ7 / clk-1. |
|---|
| Other Phenotypes | Decreased clk-1 function increases adult life-span by 30% (Lakowski and Hekimi, 1996).. |
|---|
| Homologs | S.c. CAT5
S.p. Spbc337.15c
D.m. COQ7
M.m. COQ7
H.s. COQ7
|
|---|
| Primary Reference | Felkai, S., Ewbank, J. J., Lemieux, J., Labbe, J. C., Brown, G. G., and Hekimi, S. (1999). CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO Journal 18, 1783-1792. [Abstract]
|
|---|
| Other References | Lakowski, B., and Hekimi, S. (1996). Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-3. [Abstract]
|
|---|
| Relevant Links | WormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=clk-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=175729
|
|---|
| Keywords | metabolism, signaling, mitochondria, Caenorhabditis, elegans, worm, coenzyme Q, development, rhytmic behaviors |
|---|
|