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| | Name | COX5 |
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| Organism | Podospora anserina |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | s |
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| Description | Disruption of the nuclear COX5 gene delayed senescence, increasing longevity between 7- and 15-fold in the 30 isolates tested (Dufour et al., 2000). Onset of senescence was not accompanied by the accumulation of senescence-specific mtDNA molecules (Dufour et al., 2000). |
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| Gene Function | COX5 codes for subunit V of the cytochrome c oxidase complex (Dufour et al., 2000). |
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| Other Phenotypes | Deletion of PaCOX5 results in exclusive use of the alternative respiratory pathway and a decrease in production of reactive oxygen species (Dufour et al., 2000). Moreover, accumulation of several senescence-specific mitochondrial DNA molecules is prevented in this nuclear mutant (Dufour et al., 2000) |
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| Homologs | S.c. COX5a, COX5b
S.p. Spcc338.10c
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| Primary Reference | Dufour, E., Boulay, J., Rincheval, V., and Sainsard-Chanet, A. (2000). A causal link between respiration and senescence in Podospora anserina. Proc Natl Acad Sci U S A 97, 4138-43. [Abstract]
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| Other References | N/A
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| Relevant Links | N/A
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| Keywords | Podospora anserina, metabolism, oxidative stress, mitochondria |
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