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| | Name | COX1 |
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| Organism | Podospora anserina |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Deletion |
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| Strain | s |
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| Description | Deletion of mobile group II intron (intron alpha) from COX1 doubled lifespan (Begel et al., 1999). Deletion encompassing intron alpha and its upstream exon abolished the senescence process entirely (Koll et al., 1985). |
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| Gene Function | COX1 codes for subunit I of the cytochrome c oxidase complex (Begel et al., 1999). |
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| Other Phenotypes | Deletion of the PaCOX1 intron-alpha prevented accumulation of senescence-associated DNA concatemer corresponding to this region of the mitochondrial genome (Begel et al., 1999) |
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| Homologs | S.c. COX1, AI5, AI2, AI3
S.p. cox1, cox1i1
C.e. COX1
R.n. COX1
M.m. MT-CO1
H.s. MTCO1
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| Primary Reference | Begel, O., Boulay, J., Albert, B., Dufour, E., and Sainsard-Chanet, A. (1999). Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. Mol Cell Biol 19, 4093-100. [Abstract]
Koll, F., Belcour, L., and Vierny, C. (1985). A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures. Plasmid 14, 106-17. [Abstract]
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| Other References | Sainsard-Chanet, A., Begel, O., and Belcour, L. (1993). DNA deletion of mitochondrial introns is correlated with the process of senescence in Podospora anserina. J Mol Biol 234, 1-7. [Abstract]
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| Relevant Links | N/A
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| Keywords | Podospora, anserina, metabolism, mitochondria, oxidative stress |
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