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| | Name | clk-2 |
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| Organism | Caenorhabditis elegans |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | Bristol N2 |
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| Description | At 20C, development is slowed down and adult life span is extended (Lakowski and Hekimi, 1996). |
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| Gene Function | Involved in regualting telomere length (Lim et al., 2001; Benard et al., 2001) and DNA damage response (Ahmed et al., 2001) |
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| Other Phenotypes | Mutant shows slow growth and rhythms similar to clk-1. Profound maternal and zygotic rescue. Mutation is embryonic lethal at 25C and results in some lethality at all temperatures (Lakowski and Hekimi, 1996). Mutation of clk-2 affects telomere length. One report states that clk-2 mutation results in shorter telomeres (Lim et al., 2001); however a second report contradicts this and claims that mutation of clk-2 results in elongated telomeres while overexpression shortens telomeres (Ahmed et al., 2001). Recently, CLK-2 was found to be identical to RAD-5, a DNA damage checkpoint protein. |
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| Homologs | N/A
S.c. TEL2
S.c. TEL2
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| Primary Reference | Lakowski, B., and Hekimi, S. (1996). Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-3. [Abstract]
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| Other References | Lim, C. S., Mian, I. S., Dernburg, A. F., and Campisi, J. (2001). C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol 11, 1706-10. [Abstract]
Ahmed, S., Alpi, A., Hengartner, M. O., and Gartner, A. (2001). C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr Biol 11, 1934-1944. [Abstract]
Benard, C., McCright, B., Zhang, Y., Felkai, S., Lakowski, B., and Hekimi, S. (2001). The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 12 [Abstract]
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| Relevant Links | WormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=clk-2
WormPD: http://www.proteome.com/databases/WormPD/reports/clk-2.html
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176065
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| Keywords | Caenorhabditis, elegans, worm, metabolism, telomeres, DNA damage |
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