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| | Name | ATP2 |
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| Organism | Saccharomyces cerevisiae (replicative) |
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| Aging Phenotype | N/A |
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| Allele Type | Unknown |
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| Strain | YPK9 |
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| Description | A temperature sensitive allele of ATP2 causes daughter cells derived from mother cells aged at 36C to have a life-span equal to that of the mother cells (Lai et al., 2002). |
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| Gene Function | Beta subunit of the mitochondrial F1-F0 ATPase. |
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| Other Phenotypes | The valine to isoleucine mutation at amino acid 90 does not affect growth on non-fermentable carbon sources (Lai et al., 2002). This allele is associated with loss of mitochondrial membrane potential and failure to segregate functional mitochondria to daughter cells. |
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| Homologs | S.p. ATP2
C.e. C34E10.6
D.m. ATPSYN-beta
R.n. ATP5B
M.m. ATP5B
H.s. ATP5B
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| Primary Reference | Lai, C. Y., Jaruga, E., Borghouts, C., and Jazwinski, S. M. (2002). A Mutation in the ATP2 Gene Abrogates the Age Asymmetry Between Mother and Daughter Cells of the Yeast Saccharomyces cerevisiae. Genetics 162, 73-87. [Abstract]
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| Other References | |
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| Relevant Links | SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ATP2
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| Keywords | yeast, replicative life-span, mitochondria, segregation |
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