|
| | Name | CIT2 |
|---|
| Organism | Saccharomyces cerevisiae (replicative) |
|---|
| Aging Phenotype | No effect on life-span |
|---|
| Allele Type | Deletion |
|---|
| Strain | YPK9 |
|---|
| Description | Deletion of CIT2 has no effect on life-span (Kirchman et al., 1999). CIT2 is not required for the strain specific life-span extension in petite cells. Overexpression of CIT2 has no effect on life-span (Kirchman et al., 1999). |
|---|
| Gene Function | Peroxisomal citrate synthase. |
|---|
| Other Phenotypes | CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells (Liao et al., 1991). |
|---|
| Homologs | S.c. CIT1
S.p. SPAC6C3.04
C.e. T20G5.2
D.m. CG3861, CG14740
H.s. CS
|
|---|
| Primary Reference | Kirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
|
|---|
| Other References | Liao, X. S., Small, W. C., Srere, P. A., and Butow, R. A. (1991). Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae. Mol Cell Biol 11, 38-46. [Abstract]
|
|---|
| Relevant Links | YPD: http://www.proteome.com/databases/YPD/reports/CIT2.html|Sep 20 2001 11:26:00:526AM
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=CIT2
|
|---|
| Keywords | Metabolism, Mitochondria, replicative senescence, Saccharomyces, cerevisiae, peroxisomes |
|---|
|