|
| | Name | chico |
|---|
| Organism | Drosophila melanogaster |
|---|
| Aging Phenotype | Life-span extension |
|---|
| Allele Type | Recessive |
|---|
| Strain | unknown |
|---|
| Description | Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals and 36% in heterozygous females. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span (Clancy et al., 2001) |
|---|
| Gene Function | Insulin receptor substrate. |
|---|
| Other Phenotypes | Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress (Clancy et al., 2001). |
|---|
| Homologs | N/A
|
|---|
| Primary Reference | Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-6. [Abstract]
|
|---|
| Other References | None
|
|---|
| Relevant Links | FlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0024248
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=64880
|
|---|
| Keywords | Drosophila, melanogaster, fly, starvation resistance, insulin, sterility, signaling |
|---|
|