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| | Name | CCR4 |
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| Organism | Saccharomyces cerevisiae (replicative) |
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| Aging Phenotype | Shortened life-span |
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| Allele Type | Deletion |
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| Strain | W303R |
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| Description | Deletion of CCR4 shortens life-span by approximately 80% (Kaeberlein and Guarente, 2002). SSD1-V partially suppresses the short life-span of a ccr4 mutant. |
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| Gene Function | Transcription factor involved in nonfermentative growth and cell wall stability (Denis, 1984; Chang et al., 1999). |
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| Other Phenotypes | Mutation of ccr4 results in temperature sensitivity that is suppressed by SSD1-V (Kaeberlein and Guarente, 2002). Mutation of ccr4 is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V (Kaeberlein and Guarente, 2002). |
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| Homologs | S.c. Ngl1p, Ngl2p, Cyr1p
S.p. Spcc5e4.02c, Spbc9b6.11c
C.e. ZC518.3, W02G9.5, SOC-2
D.m. CG5534, CG17741, CG4796
R.n. LOC117284, LUM, SCOP
M.m. CCR4, RSU1, FLIIH
H.s. CCRN4L, SHOC2
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| Primary Reference | Kaeberlein, M., and Guarente, L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity. Genetics 160, 83-95. [Abstract]
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| Other References | Denis, C. L. (1984). Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II. Genetics 108, 833-44. [Abstract]
Chang, M., French-Cornay, D., Fan, H. Y., Klein, H., Denis, C. L., and Jaehning, J. A. (1999). A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19, 1056-67. [Abstract]
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| Relevant Links | YPD: http://www.proteome.com/databases/YPD/reports/ccr4.html
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ccr4
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| Keywords | Saccharomyces cerevisiae, yeast, replicative, senescence, cell wall, transcription factor, signalling, |
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