gene db

Name	che-2
Organism	Caenorhabditis elegans
Aging Phenotype	Life-span extension
Allele Type	Recessive
Strain	Bristol N2
Description	Loss of function mutants extend life-span up to 50% (Apfeld and Kenyon, 1999).
Gene Function	WD40 repeat protein (Fujiwara et al. 1999).
Other Phenotypes	Mutants are chemotactic defective, slightly small and defective for osmotic avoidance. Ciliated neurons have abnormal stunted ultrastructure. Mutants are dauer defective (Perkins et al., 1988; Vowels and Thomas, 1992).
Homologs	S.c. PFS2, PWP2, PRP4, YCR072C, TAF90, SIF2 S.p. Spbc713.04C, Spac227.12, Spbc1289.11, taf72, Spbc354.03, taf73, Spcc1235.09, ... C.e. C14B1.4, K04G11.4, ZC302.2, R06A4.9, gbp-2, opu-2, ... D.m. CG9333, wds, CG17437, ebi, CG10931, BG, ... R.n. Arpc1b, Rn.2568, Gnb2, Gnb1, Strn M.m. Hira, Sid329, WSB-2, Trip1, Strap, Gnb2-rs1, ... H.s. WDR5, TBL1, FLJ11287, HPRP8BP, HIRA, SOP2L, ...
Primary Reference	Apfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other References	Perkins, L. A., Hedgecock, E. M., Thomson, J. N., and Culotti, J. G. (1986). Mutant sensory cilia in the nematode Caenorhabditis elegans. Developmental Biology 117, 456-487. [Abstract] Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Relevant Links	WormBase: http://www.wormbase.org/db/gene/locus?name=che-2;class=Locus WormPD: http://www.proteome.com/databases/WormPD/reports/che-2.html LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180401
Keywords	Caenorhabditis, elegans, worm, neurons, dauer