Nameage-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionA recessive allele of age-1 increases life-span up to 100% (Friedman and Johnson, 1988; Morris et al. 1996). Life-span extension by age-1 is up to 100% in axenic culture (Vanfleteren and Vreese, 1995).
Gene FunctionPI-3-kinase (catalytic subunit-p110)
Other PhenotypesMutant is dauer constitutive (Gottlieb and Ruvkun, 1994). Mutants display lower low brood size and increased embryonic lethality (Tissenbaum and Ruvkun, 1998). age-1 mutants also have elevated levels of superoxide dismutase and catalase activities (Vanfleteren, 1993).
HomologsS.c. YPS34, STT4, PIK1, TEL1, TOR1, MEC1
S.p. Vps34, Spbc577.06c, Spac22E12.16c
C.e. F39B1.1, let-512, Y75B8A.24, F35H12.4, atl-1, Y48G1BL.F
D.m. Pi3K92E, Pi3K68D, Pi3K59F, CG10260, CG6535
R.n. Rn.14870, Rn.30010, RN.11015, RN.14991, Frap1
M.m. Pik3ca, Pik3cd, Pik3c2a, Pi3c2g, Frap1, Prkdc, Atm
H.s. PIK3CA, PIK3CG, PIK3CB, PIK3C2A, PIK3C2G, PIK3C3, PIK4CA, PIK4CB, PIKDC, FRAP1, ATM
Primary ReferenceFriedman, D. B., and Johnson, T. E. (1988). A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86. [Abstract]
Other ReferencesGottlieb, S., and Ruvkun, G. (1994). daf-2, daf-16, and daf-23: Genetically interacting genes controlling dauer formation in C. elegans. Genetics 137, 107-120. [Abstract]
Tissenbaum, H. A., and Ruvkun, G. (1998). An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717. [Abstract]
Vanfleteren, J. R. (1993). Oxidative stress and aging in Caenorhabditis elegans. Biochem. J. 292, 605-608. [Abstract]
Vanfleteren, J. R., and de Vreese, A. (1995). The geronotogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J 9, 1355-1361. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=age-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=174762
Keywordsmetabolism, insulin, signaling, dauer, Caenorhabditis, elegans, worm, dauer, oxidative stress