|
| | Name | Ceinsulin-1 |
|---|
| Organism | Caenorhabditis elegans |
|---|
| Aging Phenotype | Life-span extension |
|---|
| Allele Type | RNAi |
|---|
| Strain | Bristol N2 |
|---|
| Description | RNAi mutants display an increased life span of around 30-40% (Kawano et al., 2000). |
|---|
| Gene Function | Insulin ligand predicted to bind DAF-2. Homologue of mammalian insulin/insulin -like growth factor (Kawano et al., 2000) |
|---|
| Other Phenotypes | RNAi animals are slow growing but do not display any dauer phenotypes (Kawano et al., 2000). |
|---|
| Homologs | C.e. F56F3.6
|
|---|
| Primary Reference | Kawano, T., Ito, Y., Ishiguro, M., Takuwa, K., Nakajima, T., and Kimura, Y. (2000). Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem Biophys Res Commun 273, 431-6.
[Abstract]
Gregoire, F. M., Chomiki, N., Kachinskas, D., and Warden, C. H. (1998). Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans, Biochem Biophys Res Commun 249, 385-390. [Abstract]
|
|---|
| Other References | None.
|
|---|
| Relevant Links | WormPD: http://www.proteome.com/databases/WormPD/reports/T28B8.2.html
WormBase: http://www.wormbase.org/perl/ace/elegans/misc/etree?name=WP%3AT28B8.2&class=Protein
|
|---|
| Keywords | metabolism, insulin, signaling, Caenorhabditis, elegans, worm |
|---|
|