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| | Name | CDC25 |
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| Organism | Saccharomyces cerevisiae (replicative) |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Recessive |
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| Strain | PSY316 |
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| Description | The cdc25-10 allele extends life-span by about 50% at 30°C. CDC25 appears to be in the same genetic pathway for longevity as SIR2 and NPT1 and has been suggested as a genetic model for caloric restriction (Lin et al., 2000). |
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| Gene Function | GDP-GTP exchange factor for Ras1p and Ras2p (Lin et al., 2000). |
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| Other Phenotypes | Null mutant is inviable (Robinson et al., 1987). |
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| Homologs | S.c. SDC25, LTE1, BUD5
S.p. efc25, ste6, imp2
C.e. Y34B4A_3.D, SOS-1
D.m. SOS, C3G, CG5522
M.m. SOS1, RASGRF2, SOS2
H.s. GRF2, SOS1
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| Primary Reference | Lin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
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| Other References | Robinson, L. C., Gibbs, J. B., Marshall, M. S., Sigal, I. S., and Tatchell, K. (1987). CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae. Science 235, 1218-21. [Abstract]
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| Relevant Links | SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=cdc25
YPD: http://www.proteome.com/databases/YPD/reports/CDC25.html
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| Keywords | caloric restriction, metabolism, signaling, cell cycle, replicative senescence, Saccharomyces, cerevisiae, yeast |
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