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| | Name | CAT |
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| Organism | Drosophila melanogaster |
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| Aging Phenotype | Life-span extension |
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| Allele Type | Overexpression |
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| Strain | unknown |
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| Description | Overexpression causes 30% lifespan extension if SOD1 (superoxide dismutase) is simultaneously overexpressed, but neither has any effect on lifespan alone (Orr and Sohal, 1994). In contrast, Sun and Tower (1999) found that overexpression of SOD1 alone was sufficient to extend lifespan. |
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| Gene Function | Catalase, converts hydrogen peroxide to water. |
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| Other Phenotypes | None. |
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| Homologs | H.s. CAT
M.m. CAT
R.n. CAT
D.m. CG9314
C.e. Y54G11A.6, CTL-2, CTL-1
S.p. cta1
S.c. CTA1, CTT1
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| Primary Reference | Orr, W. C., and Sohal, R. S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-30. [Abstract]
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| Other References | Sun, J., and Tower, J. (1999). FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 19, 216-28. [Abstract]
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| Relevant Links | FlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0000261
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=40048
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| Keywords | oxidative stress, fly, Drosophila, melanogaster, mitochondria |
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