|
| | Name | ADA1 |
|---|
| Organism | Saccharomyces cerevisiae (replicative) |
|---|
| Aging Phenotype | Shortened life-span |
|---|
| Allele Type | Deletion |
|---|
| Strain | W303-1A |
|---|
| Description | Deletion of ADA1 shortens life-span by approximately 80% (Sinclair et al., 1997). This is not a premature aging phenotype as “old” ADA1 cells do not become prematurely sterile or show other biomarkers of yeast aging (Sinclair et al., 1997; Smeal et al., 1996). |
|---|
| Gene Function | Transcription factor in ADA complex. |
|---|
| Other Phenotypes | ADA1 mutants are temperature-sensitive and respiratory-deficient (Marcus et al., 1994). |
|---|
| Homologs | S.p. Spbc887.18c
|
|---|
| Primary Reference | Sinclair, D. A., Mills, K., and Guarente, L. (1997). Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277, 1313-6. [Abstract]
|
|---|
| Other References | Marcus, G. A., Silverman, N., Berger, S. L., Horiuchi, J., and Guarente, L. (1994). Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. Embo J 13, 4807-15. [Abstract]
Smeal, T., Claus, J., Kennedy, B., Cole, F., and Guarente, L. (1996). Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84, 633-42. [Abstract]
|
|---|
| Relevant Links | SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ADA1
YPD: http://www.proteome.com/databases/YPD/reports/HFI1.html
|
|---|
| Keywords | sterility, transcription factor, replicative senescence, Saccharomyces, cerevisiae, yeast |
|---|
|