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Ms. Ordinario is continuing to study the mechanisms involved in maintaining genome stability, by
analysis of DNA damage repair and DNA recombination enzymes. The focus of her project has shifted
to studying the function of the DNA recombination complexes, MRE11/RAD50/NBS1 and the RAD51 paralogs.
Ms. Ordinario is interested in identifying the cellular localization of these complexes in response
to DNA damaging agents, such as irradiation. She is presently utilizing the DT40 cell line, a highly
recombinogenic B cell line derived from a chicken bursal lymphoma, as a model system for analysis of
these repair complexes in vertebrate cells.
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